The homeobox genes are a large and diverse group of genes, many of which play important roles in the embryonic development of animals. Increasingly, homeobox genes are being compared between genomes in an attempt to understand the evolution of animal development.

If you use HomeoDB, please cite the following publications:
Ying-Fu Zhong and Peter W H Holland (2011) HomeoDB2: functional expansion of a comparative homeobox gene database for evolutionary developmental biology. Evolution & Development. 13:6, 567-568.
Ying-Fu Zhong, Thomas Butts and Peter W H Holland (2008) HomeoDB: a database of homeobox gene diversity. Evolution & Development. 10:5, 516-518.
human mouse chicken Frog zebrafish
Human
(Homo sapiens)
Mouse
(Mus musculus)
Chicken
(Gallus gallus)
Frog
(Xenopus tropicalis)
Zebrafish
(Danio rerio)
amphioxus fly Beetle Bee Worm
Amphioxus
(Branchiostoma floridae)
Fruitfly
(Drosophila melanogaster)
Beetle
(Tribolium castaneum)
Honeybee
(Apis mellifera)
Nematode
(Caenorhabditis elegans)
homeobox genes regulation summary    
Total HomeoReg Summary    
Download | Compare | BLAST | Search (gene symbol, e.g. HOX)
Acknowledgement: The human picture is by Leonardo da Vinci (Vitruvian Man, 1492). The amphioxus picture is courtesy of Dr. Dale Stokes.
The fly picture is courtesy of Dr. Helen White-Cooper. The mouse picture is by George Shuklin from Wikipedia in the term 'Mouse'.
The worm picture is by Bob Goldstein from Wikipedia in the term 'Caenorhabditis elegans'.
The chicken picture is by Andrei from Wikipedia in the term 'Chicken'. The zebrafish picture is from Wikipedia in the term 'Zebrafish'.
Mirror Site: homeodb.zoo.ox.ac.uk