Home | Human | Mouse | Chicken | Frog | Zebrafish | Amphioxus | Fruitfly | Beetle | Honeybee | Nematode
Total | HomeoReg | Summary | Download | Compare | BLAST | Search (gene symbol, e.g. HOX)

ANTP Class
Families List  Genes List
Cdx Family
The Cdx or caudal gene family includes three human and mouse genes, one amphioxus gene and the Drosophila gene caudal (cad). The three human/mouse Cdx genes (Cdx1, Cdx2, Cdx4) were generated by genome duplication at the base of the vertebrates. The amphioxus AmphiCdx gene is part of the ParaHox gene cluster (Brooke et al. 1998). In human, the CDX2 gene is part of the ParaHox gene cluster; the other two Cdx genes are in paralogous regions of the genome (Pollard and Holland, 2000). In zebrafish and pufferfish there are also three Cdx genes, though these are not 1:1 equivalents of the mammalian Cdx genes due to duplication via the '3R' teleost-specific genome duplication and then gene loss: this left two copies of Cdx1, one of Cdx4 and no Cdx2 (Mulley et al. 2006).

Reference(s):
Brooke NM, Garcia-Fernàndez J, Holland PWH (1998) Nature 392:920-922.
Mulley JF, Chiu C, Holland PWH (2006) PNAS 103: 10369-10372.
Pollard SL, Holland PWH (2000) Curr Biol 10:1059-1062.
 
Families List of Class ANTP :
HOXL subclass
Cdx(22)Evx(17)Gbx(15)Gsx(13)Hox1(21)Hox2(13)Hox3(25)Hox4(24)Hox5(19)Hox6-8(55)
Hox9-13(15)(96)Meox(14)Mnx(15)Pdx(6)       
NKL subclass
Abox(5)Ankx(1)Barhl(16)Bari(4)Barx(10)Bsx(10)Dbx(15)Dlx(35)Emx(22)En(19)
Hhex(10)Hlx(9)Hx(1)Lbx(14)Lcx(1)Msx(22)Msxlx(3)Nanog(15)Nedx(5)Nk1(17)
Nk2.1(18)Nk2.2(15)Nk3(14)Nk4(19)Nk5/Hmx(25)Nk6(19)Nk7(4)Noto(10)Ro(5)Tlx(19)
Vax(12)Ventx(18)         
 
Loci in Cdx of All back to top..
Symbol/LocusNameFamilyOrganismRegulator
cdx1acaudal type homeo box transcription factor 1 aCdxZebrafish 
cdx1bcaudal type homeobox 1 bCdxZebrafish 
cdx4caudal type homeo box transcription factor 4CdxZebrafish 
pal-1Posterior ALae in malesCdxNematode 
Cdx1 CdxMouse 
Cdx2 CdxMouse 
Cdx4 CdxMouse 
CDX1caudal type homeobox 1CdxHuman 
CDX2caudal type homeobox 2CdxHumanhsa-mir-9
CDX4caudal type homeobox 4CdxHuman 
CadCaudalCdxHoneybee 
cadcaudalCdxFruitfly 
cdx1 caudal type homeobox 1CdxFrog 
cdx2caudal type homeobox 2CdxFrog 
cdx4caudal type homeobox 4 CdxFrog 
CDX1caudal type homeobox 1CdxChicken 
CDX2caudal type homeobox 2CdxChicken 
CDX4caudal type homeobox 4CdxChicken 
CDX4-2caudal type homeobox 4 duplicationCdxChicken 
Cad1Caudal1CdxBeetle 
Cad2Caudal2CdxBeetle 
CdxCdxCdxAmphioxus