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ANTP Class
Families List  Genes List
Dlx Family
The Dlx or Dll gene family is named after the single Drosophila representative distalless (Dll). Amphioxus also has a single member (AmphiDll; Holland et al. 1996). In human, there are six Dlx genes arranged as three pairs, each linked to a Hox gene cluster: DLX1 and DLX2 are linked to HOXD, DLX3 and DLX4 are linked to HOXB, DLX5 and DLX6 are linked to HOXA. Phylogenetic analysis reveals that these descended from an ancestral linked pair of genes (thus DLX1, 4 and 6 form a robust clade, while DLX2, 5 and 3 form a clade in some analyses; Stock et al. 1996, Holland et al. 2007). It is currently unclear if the common ancestor of Drosophila and vertebrates had one or two Dlx genes. Dlx genes have been widely studied because of their roles in limb development (Panganiban et al. 1997), although they are also involved in many other developmental processes.

Holland ND et al. (1996) Development 122:2911-2920.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Panganiban G et al. (1997) PNAS 94:5162-5166.
Stock DW et al. (1996) PNAS 93:10858-10863.
Families List of Class ANTP :
HOXL subclass
NKL subclass
Loci in Dlx of All back to top..
dlx1adistal-less homeobox gene 1aDlxZebrafish 
dlx2adistal-less homeobox gene 2aDlxZebrafish 
dlx2bdistal-less homeobox gene 2bDlxZebrafish 
dlx3bdistal-less homeobox gene 3bDlxZebrafish 
dlx4adistal-less homeobox gene 4aDlxZebrafish 
dlx4bdistal-less homeobox gene 4bDlxZebrafish 
dlx5adistal-less homeobox gene 5aDlxZebrafish 
dlx6adistal-less homeobox gene 6aDlxZebrafish 
ceh-43C. Elegans Homeobox 43DlxNematode 
Dlx1 DlxMouse 
Dlx2 DlxMouse 
Dlx3 DlxMouse 
Dlx4 DlxMouse 
Dlx5 DlxMousemmu-mir-141; mmu-mir-200a
Dlx6 DlxMouse 
DLX1distal-less homeobox 1DlxHuman 
DLX2distal-less homeobox 2DlxHuman 
DLX3distal-less homeobox 3DlxHuman 
DLX4distal-less homeobox 4DlxHuman 
DLX5distal-less homeobox 5DlxHuman 
DLX6distal-less homeobox 6DlxHuman 
dlx1distal-less homeobox 1 DlxFrog 
dlx2distal-less homeobox 2 DlxFrog 
dlx3distal-less homeobox 3DlxFrog 
dlx4distal-less homeobox 4DlxFrog 
dlx5distal-less homeobox 5 DlxFrog 
dlx6distal-less homeobox 6DlxFrog 
DLX1distal-less homeobox 1DlxChicken 
Dlx3-lDlx3 likeDlxChicken 
DLX5distal-less homeobox 5DlxChicken 
DLX6distal-less homeobox 6DlxChicken