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ANTP Class
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En Family
The En or engrailed gene family includes two human genes, one amphioxus gene (AmphiEn) and two tandemly arranged Drosophila genes (en and inv). The relatively close linkage of mammalian Gbx genes to MNX1 and EN2 originally suggested they may be part of a gene cluster (EHGbox; Pollard and Holland 2000); however subsequent genome sequencing revealed the genes are not immediate neighbours and hence it is more accurate to consider Gbx, Mnx and En genes as derivatives of extensive tandem gene duplication events that gave rise to much of the ANTP class diversity early in animal evolution (Castro and Holland 2003).

Reference(s):
Castro LFC, Holland PWH (2003) Evol Dev 5:459-465. Pollard SL, Holland PWH (2000) Curr Biol 10:1059-1062.
 
Families List of Class ANTP :
HOXL subclass
Cdx(3)Evx(2)Gbx(3)Gsx(2)Hox1(3)Hox2(2)Hox3(4)Hox4(4)Hox5(3)Hox6-8(8)
Hox9-13(15)(15)Meox(1)Mnx(2)Pdx(1)       
NKL subclass
Barhl(2)Barx(2)Bsx(1)Dbx(2)Dlx(6)Emx(4)En(2)Hhex(2)Hlx(1)Lbx(1)
Msx(2)Nk1(3)Nk2.1(4)Nk2.2(2)Nk3(3)Nk4(3)Nk5/Hmx(5)Nk6(3)Noto(1)Tlx(3)
Vax(2)Ventx(6)         
 
Loci in En of Frog back to top..
Symbol/LocusNameFamilyOrganismRegulator
en1engrailed homeobox 1EnFrog 
en2engrailed homeobox 2 EnFrog