Home | Human | Mouse | Chicken | Frog | Zebrafish | Amphioxus | Fruitfly | Beetle | Honeybee | Nematode
Total | HomeoReg | Summary | Download | Compare | BLAST | Search (gene symbol, e.g. HOX)

ANTP Class
Families List  Genes List
Nk2.2 Family
The Nk2-2 gene family is named after the NK2 or vnd gene in Drosophila. vnd is not part of the NK or 93DE homeobox gene cluster. In humans, there are two Nk2-2 genes (NKX2-2, NKX2-8), on different chromosomes, generated by genome duplication at the base of the vertebrates. Amphioxus has a single Nk2-2 gene. Nk2-2 genes are usually physically adjacent to Nk2-1 genes.

The nomenclature of Nk2 genes is very confusing. The human genome has seven genes with the prefix NK2; these divide into three distinct gene families as follows: NKX2-1 and NKX2-4 form the Nk2-1 family (with the Drosophila gene scro), NKX2-2 and NKX2-8 form the Nk2-2 family (with the Drosophila gene vnd), NKX2-3, NKX2-5 and NKX2-6 form the NK4 gene family (with the Drosophila gene tin). Renaming the Nk4 genes, for example to CSX1, CSX2, CSX3, would help to simplify the nomenclature.

Reference(s):
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
 
Families List of Class ANTP :
HOXL subclass
Cdx(2)Evx(1)Gbx(1)Gsx(1)Hox1(1)Hox2(1)Hox3(2)Hox4(1)Hox5(1)Hox6-8(4)
Hox9-13(15)(1)Meox(1)Mnx(1)        
NKL subclass
Abox(1)Barhl(1)Bari(1)Bsx(1)Dbx(1)Dlx(1)Emx(1)En(2)Hhex(1)Hlx(1)
Lbx(1)Msx(2)Msxlx(1)Nedx(1)Nk1(1)Nk2.1(1)Nk2.2(1)Nk3(1)Nk4(1)Nk5/Hmx(1)
Nk6(1)Nk7(1)Noto(1)Ro(1)Tlx(1)      
 
Loci in Nk2.2 of Beetle back to top..
Symbol/LocusNameFamilyOrganismRegulator
VndVentral nervous system defectiveNk2.2Beetle