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ANTP Class
Families List  Genes List
Nk2.2 Family
The Nk2-2 gene family is named after the NK2 or vnd gene in Drosophila. vnd is not part of the NK or 93DE homeobox gene cluster. In humans, there are two Nk2-2 genes (NKX2-2, NKX2-8), on different chromosomes, generated by genome duplication at the base of the vertebrates. Amphioxus has a single Nk2-2 gene. Nk2-2 genes are usually physically adjacent to Nk2-1 genes.

The nomenclature of Nk2 genes is very confusing. The human genome has seven genes with the prefix NK2; these divide into three distinct gene families as follows: NKX2-1 and NKX2-4 form the Nk2-1 family (with the Drosophila gene scro), NKX2-2 and NKX2-8 form the Nk2-2 family (with the Drosophila gene vnd), NKX2-3, NKX2-5 and NKX2-6 form the NK4 gene family (with the Drosophila gene tin). Renaming the Nk4 genes, for example to CSX1, CSX2, CSX3, would help to simplify the nomenclature.

Reference(s):
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
 
Families List of Class ANTP :
HOXL subclass
Cdx(3)Evx(2)Gbx(2)Gsx(2)Hox1(3)Hox2(2)Hox3(3)Hox4(4)Hox5(3)Hox6-8(8)
Hox9-13(15)(16)Meox(2)Mnx(1)Pdx(1)       
NKL subclass
Barhl(2)Barx(2)Bsx(1)Dbx(2)Dlx(6)Emx(2)En(2)Hhex(1)Hlx(1)Lbx(2)
Msx(3)Nanog(3)Nk1(2)Nk2.1(2)Nk2.2(2)Nk3(2)Nk4(3)Nk5/Hmx(3)Nk6(3)Noto(1)
Tlx(3)Vax(2)         
 
Loci in Nk2.2 of Mouse back to top..
Symbol/LocusNameFamilyOrganismRegulator
Nkx2-2 Nk2.2Mouse 
Nkx2-9 Nk2.2Mouse