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ANTP Class
Families List  Genes List
Nk2.2 Family
The Nk2-2 gene family is named after the NK2 or vnd gene in Drosophila. vnd is not part of the NK or 93DE homeobox gene cluster. In humans, there are two Nk2-2 genes (NKX2-2, NKX2-8), on different chromosomes, generated by genome duplication at the base of the vertebrates. Amphioxus has a single Nk2-2 gene. Nk2-2 genes are usually physically adjacent to Nk2-1 genes.

The nomenclature of Nk2 genes is very confusing. The human genome has seven genes with the prefix NK2; these divide into three distinct gene families as follows: NKX2-1 and NKX2-4 form the Nk2-1 family (with the Drosophila gene scro), NKX2-2 and NKX2-8 form the Nk2-2 family (with the Drosophila gene vnd), NKX2-3, NKX2-5 and NKX2-6 form the NK4 gene family (with the Drosophila gene tin). Renaming the Nk4 genes, for example to CSX1, CSX2, CSX3, would help to simplify the nomenclature.

Reference(s):
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
 
Families List of Class ANTP :
HOXL subclass
Cdx(3)Evx(3)Gbx(2)Gsx(2)Hox1(4)Hox2(2)Hox3(5)Hox4(4)Hox5(4)Hox6-8(8)
Hox9-13(15)(24)Meox(3)Mnx(3)Pdx(1)       
NKL subclass
Barhl(3)Barx(2)Bsx(1)Dbx(3)Dlx(8)Emx(3)En(4)Hhex(1)Hlx(1)Lbx(3)
Msx(5)Nk1(2)Nk2.1(3)Nk2.2(3)Nk3(3)Nk4(3)Nk5/Hmx(5)Nk6(3)Noto(1)Tlx(4)
Vax(2)Ventx(1)         
 
Loci in Nk2.2 of Zebrafish back to top..
Symbol/LocusNameFamilyOrganismRegulator
nkx2.2aNK2 transcription factor related 2aNk2.2Zebrafish 
nkx2.2bNK2 transcription factor related 2bNk2.2Zebrafish 
nkx2.9NK2 transcription factor related, locus 9Nk2.2Zebrafish