Home | Human | Mouse | Chicken | Frog | Zebrafish | Amphioxus | Fruitfly | Beetle | Honeybee | Nematode
Total | HomeoReg | Summary | Download | Compare | BLAST | Search (gene symbol, e.g. HOX)

ANTP Class
Families List  Genes List
Tlx Family
The Tlx gene family is named after a human gene TLX1, a breakpoint in which is associated with T-cell leukemia. In humans, there are three TLX genes (TLX1, 2, 3), which have undergone several nomenclature revisions; the early designations HOX11, HOX11L1 and HOX11L2 were particularly unfortunate as they are not Hox genes. Amphioxus has a single Tlx gene; the single Drosophila Tlx gene (C15) is part of the NK or 93DE homeobox gene cluster (Jagla et al. 2001). The NK gene cluster has broken in chordates (Luke et al. 2001). Tlx genes are usually physically adjacent to Lbx genes.

Reference(s):
Jagla K, Bellard M, Frasch M (2001) BioEssays 23: 125-133. Luke GN et al. (2001) PNAS 100:5292-5295.
 
Families List of Class ANTP :
HOXL subclass
Cdx(22)Evx(17)Gbx(15)Gsx(13)Hox1(21)Hox2(13)Hox3(25)Hox4(24)Hox5(19)Hox6-8(55)
Hox9-13(15)(96)Meox(14)Mnx(15)Pdx(6)       
NKL subclass
Abox(5)Ankx(1)Barhl(16)Bari(4)Barx(10)Bsx(10)Dbx(15)Dlx(35)Emx(22)En(19)
Hhex(10)Hlx(9)Hx(1)Lbx(14)Lcx(1)Msx(22)Msxlx(3)Nanog(15)Nedx(5)Nk1(17)
Nk2.1(18)Nk2.2(15)Nk3(14)Nk4(19)Nk5/Hmx(25)Nk6(19)Nk7(4)Noto(10)Ro(5)Tlx(19)
Vax(12)Ventx(18)         
 
Loci in Tlx of All back to top..
Symbol/LocusNameFamilyOrganismRegulator
LOC100008066T-cell leukemia, homeobox 3b-likeTlxZebrafish 
tlx1T-cell leukemia, homeobox 1TlxZebrafish 
tlx2T-cell leukemia, homeobox 2TlxZebrafish 
tlx3bT-cell leukemia, homeobox 3bTlxZebrafish 
Tlx1 TlxMouse 
Tlx2 TlxMouse 
Tlx3 TlxMouse 
TLX1T-cell leukemia homeobox 1TlxHuman 
TLX2T-cell leukemia homeobox 2TlxHuman 
TLX3T-cell leukemia homeobox 3TlxHuman 
C15C15TlxHoneybee 
C15C15TlxFruitfly 
tlx1T-cell leukemia homeobox 1 TlxFrog 
tlx2T-cell leukemia homeobox 2TlxFrog 
tlx3T-cell leukemia homeobox 3TlxFrog 
TLX1T-cell leukemia homeobox 1TlxChicken 
TLX3T-cell leukemia homeobox 3TlxChicken 
C15C15TlxBeetle 
TlxTlxTlxAmphioxus