The Tlx gene family is named after a human gene TLX1, a breakpoint in which is associated with T-cell leukemia. In humans, there are three TLX genes (TLX1, 2, 3), which have undergone several nomenclature revisions; the early designations HOX11, HOX11L1 and HOX11L2 were particularly unfortunate as they are not Hox genes. Amphioxus has a single Tlx gene; the single Drosophila Tlx gene (C15) is part of the NK or 93DE homeobox gene cluster (Jagla et al. 2001). The NK gene cluster has broken in chordates (Luke et al. 2001). Tlx genes are usually physically adjacent to Lbx genes.|
Jagla K, Bellard M, Frasch M (2001) BioEssays 23: 125-133.
Luke GN et al. (2001) PNAS 100:5292-5295.