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CERS Class
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Cers Family
The CERS (or LASS) homeobox gene class is highly unusual and encodes proteins that seem to be transmembrane in nature (Mizutani and Kihara 2005; Pewzner-Jung et al. 2006). The function of the homeodomain in these proteins is unknown. There are six CERS (ceramide synthase) genes in the human genome, but only five of these include a homeobox sequence and are therefore included in the CERS homeobox gene class (Holland et al. 2007). Amphioxus has a single CERS homeobox gene.

Reference(s):
Mizutani Y, Kihara A, Igarashi Y (2005) Biochem J 2005, 390:263-271.
Pewzner-Jung Y, Ben-Dor S, Futerman AH (2006) J Biol Chem 281:25001-25005.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
 
Families List of Class CERS :
Cers(26)         
 
Loci in Cers of All back to top..
Symbol/LocusNameFamilyOrganismRegulator
Cers-lLAG1 homolog, ceramide synthase likeCersZebrafish 
Cers-lnovel protein similar to LAG1 homolog, ceramide synthase familyCersZebrafish 
lass5LAG1 homolog, ceramide synthase 5CersZebrafish 
Lass2 CersMouse 
Lass3 CersMouse 
Lass4 CersMouse 
Lass5 CersMouse 
Lass6 CersMouse 
CERS2ceramide synthase 2CersHuman 
CERS3ceramide synthase 3CersHuman 
CERS4ceramide synthase 4CersHuman 
CERS5ceramide synthase 5CersHuman 
CERS6ceramide synthase 6CersHuman 
Lag1Longevity assurance gene 1CersHoneybee 
Lag1Longevity assurance gene 1CersFruitfly 
lass5LAG1 homolog, ceramide synthase 5 CersFrog 
lass6LAG1 homolog, ceramide synthase 6 CersFrog 
Cers-lCers likeCersChicken 
LASS2LAG1 homolog, ceramide synthase 2CersChicken 
LASS3LAG1 homolog, ceramide synthase 3CersChicken 
LASS4LAG1 homolog, ceramide synthase 4CersChicken 
LASS6LAG1 homolog, ceramide synthase 6CersChicken 
LOC415513similar to LASS3 proteinCersChicken 
Lag1aLongevity assurance gene 1aCersBeetle 
Lag1bLongevity assurance gene 1bCersBeetle 
CersCersCersAmphioxus