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PRD Class
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Otx Family
The Otx (or otd) gene family was originally defined by the Drosophila gene orthodenticle (otd), also called ocelliless (oc), and two orthologues in mouse and human (OTX1, OTX2). Attention was drawn to their shared expression in anterior body regions and the developing brain (Simeone et al.1992). It was later shown that a third Otx gene (CRX), expressed in eye development, is present in humans and other vertebrates (Plouhinec et al. 2003). (The CRX gene would ideally be named OTX3 except that this name was formerly used erroneously for the distantly related Dmbx gene). There is also one OTX2 pseudogene in humans. Amphioxus has a single Otx gene.

Reference(s):
Simeone A et al. (1992) Nature 358:687-690.
Plouhinec J-L et al. (2003) Mol Biol Evol 20:513-521.
 
Families List of Class PRD :
Alx(16)AprdA(1)AprdB(1)AprdC(1)AprdD(2)AprdE(1)Argfx(3)Arx(14)CG11294(3)
Dmbx(8)Dprx(8)Drgx(9)Dux(42)Esx(2)Gsc(14)Hbn(3)Hesx(5)Hopx(5)
Isx(5)Leutx(1)Mix(7)Nobox(5)Obox(36)Otp(12)Otx(24)Pax2/5/8(12)Pax3/7(24)
Pax4/6(24)Phox(17)Pitx(20)Prop(8)Prrx(14)Rax(14)Repo(4)Rhox(39)Sebox(3)
Shox(12)Tprx(5)Uncx(16)Vsx(18)      
 
Loci in Otx of All back to top..
Symbol/LocusNameFamilyOrganismRegulator
crxcone-rod homeoboxOtxZebrafish 
otx1aorthodenticle homolog 1aOtxZebrafish 
otx1borthodenticle homolog 1bOtxZebrafish 
otx2orthodenticle homolog 2OtxZebrafish 
otx5orthodenticle homolog 5OtxZebrafish 
ceh-36C. Elegans Homeobox 36OtxNematode 
ceh-37C. Elegans Homeobox 37OtxNematode 
ttx-1abnormal ThermoTaXis 1OtxNematode 
Crx OtxMouse 
Otx1 OtxMouse 
Otx2 OtxMouse 
CRXcone-rod homeoboxOtxHuman 
OTX1orthodenticle homeobox 1OtxHuman 
OTX2orthodenticle homeobox 2OtxHuman 
OTX2P1orthodenticle homeobox 2 pseudogeneOtxHuman 
Oc1Ocelliless1OtxHoneybee 
Oc2Ocelliless2OtxHoneybee 
ococellilessOtxFruitfly 
crxcone-rod homeobox OtxFrog 
otx1orthodenticle homeobox 1 OtxFrog 
otx2orthodenticle homeobox 2OtxFrog 
Oc1Ocelliless1OtxBeetle 
Oc2Ocelliless2OtxBeetle 
OtxOtxOtxAmphioxus