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ANTP Class
Families List  Genes List
The ANTP class is the largest of the homeobox gene classes in animal genomes. Thus far, these genes have only been found in animals. The ANTP class derives its name from (but is not an abbreviation for) the Antennapedia (Antp) gene of Drosophila. Although the best known ANTP class genes are the Hox genes, these comprise a minority of ANTP class genes. The human and mouse genomes each have 39 HOX genes, amongst a total of 100 ANTP genes (Holland et al. 2007; Zhong and Holland, 2011); there are also 19 ANTP pseudogenes described in the human genome and 2 in mouse. The amphioxus genome has 60 ANTP genes including 15 Hox genes (Takatori et al. 2008); Drosophila melanogaster has 47 ANTP class genes.

Following Holland et al. (2007) we subdivide the ANTP class into numerous gene families (e.g. 37 families in human); these are sometimes grouped into two relatively well-supported subclasses (HOXL and the NKL subclasses, meaning Hox-like and NK-like), although a few genes are hard to place in either the HOXL and NKL groups; another suggestion is to divide the class on the basis of chromosomal position (Hox-linked and NK-linked; Ferrier 2010).

Reference(s):
Ferrier DEK (2010) Adv Exp Med Biol 689: 91-100.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Takatori N et al (2008) Dev Genes Evol 218: 579-590.
Zhong YF, Holland PWH (2011) BMC Evol Biol 11: 169-204.
 
Families List of Class ANTP :
HOXL subclass
Cdx(2)Evx(1)Gbx(1)Gsx(1)Hox1(1)Hox2(1)Hox3(2)Hox4(1)Hox5(1)Hox6-8(4)
Hox9-13(15)(1)Meox(1)Mnx(1)        
NKL subclass
Abox(1)Barhl(1)Bari(1)Bsx(1)Dbx(1)Dlx(1)Emx(1)En(2)Hhex(1)Hlx(1)
Lbx(1)Msx(2)Msxlx(1)Nedx(1)Nk1(1)Nk2.1(1)Nk2.2(1)Nk3(1)Nk4(1)Nk5/Hmx(1)
Nk6(1)Nk7(1)Noto(1)Ro(1)Tlx(1)      
 
Loci in ANTP of Beetle back to top..
Symbol/LocusNameFamilyOrganismRegulator
abd-Aabdominal-AHox6-8Beetle 
Abd-BAbdominal-BHox9-13(15)Beetle 
AboxAbsent from Olfactores HomeoboxAboxBeetle 
B-HBarHBarhlBeetle 
BapBagpipeNk3Beetle 
BariBariBariBeetle 
BshBrain-specific homeoboxBsxBeetle 
BtnButtonlessMeoxBeetle 
C15C15TlxBeetle 
Cad1Caudal1CdxBeetle 
Cad2Caudal2CdxBeetle 
CxCephalothoraxHox5Beetle 
DbxDeveloping brain homeoboxDbxBeetle 
DfdDeformedHox4Beetle 
DllDistallessDlxBeetle 
Dr1Drop1MsxBeetle 
Dr2Drop2MsxBeetle 
EmsEmpty spiraclesEmxBeetle 
EnEngrailedEnBeetle 
EveEven skippedEvxBeetle 
ExexExtra ExtraMnxBeetle 
ftzfushi tarazuHox6-8Beetle 
H2.0Homeodomain protein 2.0HlxBeetle 
HexHexHhexBeetle 
HgtxHgtxNk6Beetle 
HmxH6-like homeoboxNk5/HmxBeetle 
IndIntermediate Neuroblasts DefectiveGsxBeetle 
InvInvectedEnBeetle 
lablabialHox1Beetle 
LbxLadybirdLbxBeetle 
MsxlxMsx-likeMsxlxBeetle 
mxpmaxillopediaHox2Beetle 
NedxNedxNedxBeetle 
NK7NK7Nk7Beetle 
NotNotNotoBeetle 
ptlprothoraxlessHox6-8Beetle 
RoRoughRoBeetle 
ScroScarecrowNk2.1Beetle 
SlouSlouchNk1Beetle 
TinTinmanNk4Beetle 
UnpgUnpluggedGbxBeetle 
UtxUltrathoraxHox6-8Beetle 
VndVentral nervous system defectiveNk2.2Beetle 
zen1zerknuellt1Hox3Beetle 
zen2zerknuellt2Hox3Beetle