Home | Human | Mouse | Chicken | Frog | Zebrafish | Amphioxus | Fruitfly | Beetle | Honeybee | Nematode
Total | HomeoReg | Summary | Download | Compare | BLAST | Search (gene symbol, e.g. HOX)

LIM Class
Families List  Genes List
The LIM homeobox gene class includes proteins with LIM domains (zinc-finger-containing protein-protein interaction domains) and a homeodomain. There are other genes that encode LIM domains but not homeodomains; these are not included. The term LIM is derived from the nematode lin-11, mammalian Isl1 and nematode mec-3 genes. There are 12 LIM class homeobox genes in the human genome, in six gene families, and no pseudogenes. There are 7 LIM class homeobox genes in amphioxus (Takatori et al. 2008)

Reference(s):
Hobert O, Westphal H (2000) Trends in Genetics 16:75-83.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Takatori N et al (2008) Dev Genes Evol 218: 579-590.
 
Families List of Class LIM :
Isl(14)Lhx1/5(17)Lhx2/9(19)Lhx3/4(15)Lhx6/8(18)Lmx(21)    
 
Loci in LIM of All back to top..
Symbol/LocusNameFamilyOrganismRegulator
isl1islet1IslZebrafish 
isl1lislet1, likeIslZebrafish 
isl2aislet2aIslZebrafish 
isl2bislet2bIslZebrafish 
lhx1aLIM homeobox 1aLhx1/5Zebrafish 
lhx1bLIM homeobox 1bLhx1/5Zebrafish 
lhx2aLIM homeobox 2aLhx2/9Zebrafish 
lhx2bLIM homeobox 2bLhx2/9Zebrafish 
lhx3LIM homeobox 3Lhx3/4Zebrafish 
Lhx3/4-lLhx3/4 likeLhx3/4Zebrafish 
lhx5LIM homeobox 5Lhx1/5Zebrafish 
lhx6LIM homeobox 6Lhx6/8Zebrafish 
lhx6-lLIM domain family member (lim-6)-likeLhx6/8Zebrafish 
Lhx6/8-lLhx6/8 likeLhx6/8Zebrafish 
lhx8aLIM homeobox 8aLhx6/8Zebrafish 
lhx9LIM homeobox 9Lhx2/9Zebrafish 
Lmx-lLmx likeLmxZebrafish 
lmx1b.1LIM homeobox transcription factor 1, beta 1LmxZebrafish 
lmx1b.2LIM homeobox transcription factor 1, beta 2LmxZebrafish 
si:ch211-260g14.3si:ch211-260g14.3LmxZebrafish 
ceh-14C. Elegans Homeobox 14Lhx3/4Nematode 
lim-4LIM domain familyLhx6/8Nematode 
lim-6LIM domain familyLmxNematode 
lim-7LIM domain family 7IslNematode 
lin-11abnormal cell LINeageLhx1/5Nematode 
mec-3MEChanosensory abnormality 3Lhx1/5Nematode 
ttx-3abnormal ThermoTaXis 3Lhx2/9Nematode 
Isl1 IslMousemmu-mir-17
Isl2 IslMouse 
Lhx1 Lhx1/5Mouse 
Lhx2 Lhx2/9Mouse 
Lhx3 Lhx3/4Mouse 
Lhx4 Lhx3/4Mouse 
Lhx5 Lhx1/5Mouse 
Lhx6 Lhx6/8Mouse 
Lhx8 Lhx6/8Mouse 
Lhx9 Lhx2/9Mouse 
Lmx1a LmxMouse 
Lmx1b LmxMouse 
ISL1ISL LIM homeobox 1IslHuman 
ISL2ISL LIM homeobox 2IslHuman 
LHX1LIM homeobox 1Lhx1/5Human 
LHX2LIM homeobox 2Lhx2/9Human 
LHX3LIM homeobox 3Lhx3/4Human 
LHX4LIM homeobox 4Lhx3/4Human 
LHX5LIM homeobox 5Lhx1/5Human 
LHX6LIM homeobox 6Lhx6/8Human 
LHX8LIM homeobox 8Lhx6/8Human 
LHX9LIM homeobox 9Lhx2/9Human 
LMX1ALMX LIM homeobox 1ALmxHuman 
LMX1BLMX LIM homeobox 1BLmxHuman 
Ap1Apterous1Lhx2/9Honeybee 
Ap2Apterous2Lhx2/9Honeybee 
Awh1Arrowhead1Lhx6/8Honeybee 
Awh2Arrowhead2Lhx6/8Honeybee 
Lim1Lim1Lhx1/5Honeybee 
Lim3Lim3Lhx3/4Honeybee 
LmxbLmxbLmxHoneybee 
TupTailupIslHoneybee 
apapterousLhx2/9Fruitfly 
AwhArrowheadLhx6/8Fruitfly 
CG32105CG32105LmxFruitfly 
CG4328CG4328LmxFruitfly 
Lim1Lim1Lhx1/5Fruitfly 
Lim3Lim3Lhx3/4Fruitfly 
isl2ISL LIM homeobox 2IslFrog 
lhx1LIM homeobox 1 Lhx1/5Frog 
lhx2LIM homeobox 2Lhx2/9Frog 
lhx3LIM homeobox 3 Lhx3/4Frog 
lhx4LIM homeobox 4 Lhx3/4Frog 
lhx5LIM homeobox 5 Lhx1/5Frog 
lhx6LIM homeobox 6 Lhx6/8Frog 
lhx8LIM homeobox 8Lhx6/8Frog 
lhx9LIM homeobox 9 Lhx2/9Frog 
lmx1aLIM homeobox transcription factor 1a LmxFrog 
lmx1bLIM homeobox transcription factor 1b LmxFrog 
lmx1cLIM homeobox transcription factor 1cLmxFrog 
ISL1ISL LIM homeobox 1IslChicken 
LHX1LIM homeobox 1Lhx1/5Chicken 
LHX2LIM homeobox 2Lhx2/9Chicken 
LHX3LIM homeobox 3Lhx3/4Chicken 
Lhx4-lLhx4 likeLhx3/4Chicken 
LHX5LIM homeobox 5Lhx1/5Chicken 
LHX6LIM homeobox 6Lhx6/8Chicken 
LHX8LIM homeobox 8Lhx6/8Chicken 
LHX9LIM homeobox 9Lhx2/9Chicken 
Lmx-lLmx likeLmxChicken 
LMX1BLIM homeobox transcription factor 1, betaLmxChicken 
LOC770725similar to LIM homeobox transcription factorLmxChicken 
Ap1Apterous1Lhx2/9Beetle 
Ap2Apterous2Lhx2/9Beetle 
AwhArrowheadLhx6/8Beetle 
Lim1Lim1Lhx1/5Beetle 
Lim3Lim3Lhx3/4Beetle 
LmxaLmxaLmxBeetle 
LmxbLmxbLmxBeetle 
TupTailupIslBeetle 
IslIslIslAmphioxus 
Lhx1/5Lhx1/5Lhx1/5Amphioxus 
Lhx2/9-aLhx2/9-aLhx2/9Amphioxus 
Lhx2/9-bLhx2/9-bLhx2/9Amphioxus 
Lhx3/4Lhx3/4Lhx3/4Amphioxus 
Lhx6/8Lhx6/8Lhx6/8Amphioxus 
LmxLmxLmxAmphioxus