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POU Class
Families List  Genes List
Proteins encoded by POU class homeobox genes have a ~75 amino acid POU-specific domain (named from the mammalian genes Pit1 (now Pou1f1), OCT1 and OCT2 (now POU2F1 and POU2F2), and nematode unc-86) N-terminal to a 60-amino acid homeodomain. Together the two domains are known as the bipartite POU domain. There are 15 genes with this structure in the human genome, plus a 16th gene (HDX) that possesses a homeodomain related to POU-type homeodomains but lacking a POU-specific domain. Including the divergent HDX gene, this gene class has 16 human genes in seven gene families; there are also eight pseudogenes (Ryan and Rosenfeld 1997, Holland et al. 2007). Amphioxus has seven genes in six families (Takatori et al. 2008).

Ryan AK, Rosenfeld MG (1997) Genes Dev 1997, 11:1207-1225.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Takatori N et al (2008) Dev Genes Evol 218: 579-590.
Families List of Class POU :
Loci in POU of All back to top..
brn1.2brain POU domain gene 1.2Pou3Zebrafish 
LOC100001518POU domain, class 6, transcription factor 2-likePou6Zebrafish 
LOC797948highly divergent homeoboxHdxZebrafish 
pou1f1POU domain, class 1, transcription factor 1Pou1Zebrafish 
Pou2-lPou2 likePou2Zebrafish 
pou2f1aPOU class 2 homeobox 1aPou2Zebrafish 
pou2f1bPOU class 2 homeobox 1bPou2Zebrafish 
pou2f2POU domain, class 2, transcription factor 2-likePou2Zebrafish 
pou3f1POU class 3 homeobox 1Pou3Zebrafish 
pou3f2POU class 3 homeobox 2Pou3Zebrafish 
pou3f3aPOU class 3 homeobox 3aPou3Zebrafish 
pou3f3bPOU class 3 homeobox 3bPou3Zebrafish 
pou4f1POU domain, class 4, transcription factor 1Pou4Zebrafish 
pou4f2POU domain, class 4, transcription factor 2Pou4Zebrafish 
pou4f3POU domain, class 4, transcription factor 3Pou4Zebrafish 
pou5f1POU domain, class 5, transcription factor 1Pou3Zebrafish 
pou6f1POU class 6 homeobox 1Pou6Zebrafish 
si:dkey-3j24.1POU domain, class 2, transcription factor 2-likePou2Zebrafish 
C02F12.10 Pou2Nematode 
ceh-18C. Elegans Homeobox 18Pou2Nematode 
ceh-6C. Elegans Homeobox 6Pou3Nematode 
unc-86UNCoordinated 86Pou4Nematode 
Hdx HdxMouse 
Pou1f1 Pou1Mouse 
Pou2f1 Pou2Mouse 
Pou2f2 Pou2Mouse 
Pou2f3 Pou2Mouse 
Pou3f1 Pou3Mouse 
Pou3f2 Pou3Mouse 
Pou3f3 Pou3Mouse 
Pou3f4 Pou3Mouse 
Pou4f1 Pou4Mouse 
Pou4f2 Pou4Mouse 
Pou4f3 Pou4Mouse 
Pou5f1 Pou5Mouse 
Pou5f2 Pou5Mouse 
Pou6f1 Pou6Mouse 
Pou6f2 Pou6Mouse 
HDXhighly divergent homeoboxHdxHuman 
POU1F1POU class 1 homeobox 1Pou1Human 
POU2F1POU class 2 homeobox 1Pou2Human 
POU2F2POU class 2 homeobox 2Pou2Human 
POU2F3POU class 2 homeobox 3Pou2Human 
POU3F1POU class 3 homeobox 1Pou3Human 
POU3F2POU class 3 homeobox 2Pou3Human 
POU3F3POU class 3 homeobox 3Pou3Human 
POU3F4POU class 3 homeobox 4Pou3Human 
POU4F1POU class 4 homeobox 1Pou4Human 
POU4F2POU class 4 homeobox 2Pou4Human 
POU4F3POU class 4 homeobox 3Pou4Human 
POU5F1POU class 5 homeobox 1Pou5Human 
POU5F1P1POU class 5 homeobox 1 pseudogene 1Pou5Human 
POU5F1P2POU class 5 homeobox 1 pseudogene 2Pou5Human 
POU5F1P3POU class 5 homeobox 1 pseudogene 3Pou5Human 
POU5F1P4POU class 5 homeobox 1 pseudogene 4Pou5Human 
POU5F1P5POU class 5 homeobox 1 pseudogene 5Pou5Human 
POU5F1P6POU class 5 homeobox 1 pseudogene 6Pou5Human 
POU5F1P7POU class 5 homeobox 1 pseudogene 7Pou5Human 
POU5F1P8POU class 5 homeobox 1 pseudogene 8Pou5Human 
POU5F2POU class 5 homeobox 2Pou5Human 
POU6F1POU class 6 homeobox 1Pou6Human 
POU6F2POU class 6 homeobox 2Pou6Human 
Acj6Abnormal chemosensory jump 6Pou4Honeybee 
Pdm3Pou domain motif 3Pou6Honeybee 
VvlVentral veins lackingPou3Honeybee 
acj6abnormal chemosensory jump 6Pou4Fruitfly 
pdm2POU domain protein 2Pou2Fruitfly 
pdm3pou domain motif 3Pou6Fruitfly 
vvlventral veins lackingPou3Fruitfly 
hdxhighly divergent homeobox HdxFrog 
oct25POU class V protein oct-25Pou3Frog 
oct60POU class V protein oct-60Pou3Frog 
pou1f1POU class 1 homeobox 1 Pou1Frog 
pou2f1POU class 2 homeobox 1 Pou2Frog 
pou2f3POU class 2 homeobox 3Pou2Frog 
pou3f1POU class 3 homeobox 1 Pou3Frog 
pou3f1bPOU class 3 homeobox 1 Pou3Frog 
pou3f2 Pou3Frog 
pou3f3POU class 3 homeobox 3Pou3Frog 
pou3f4POU class 3 homeobox 4 Pou3Frog 
pou4f1POU class 4 homeobox 1 Pou4Frog 
pou4f1.2POU class 4 homeobox 1Pou4Frog 
pou4f2POU class 4 homeobox 2Pou4Frog 
pou4f3POU class 4 homeobox 3 Pou4Frog 
pou5f1 Pou3Frog 
pou6f1POU class 6 homeobox 1Pou6Frog 
pou6f1b Pou6Frog 
pou6f2POU class 6 homeobox 2 Pou6Frog 
HDXhighly divergent homeoboxHdxChicken 
LOC428735similar to POU domain, class 4, transcription factor 2 (Brain-specific homeobox/POU domain protein 3B) (Brn-3B) (Brn-3.2)Pou4Chicken 
POU1F1POU domain, class 1, transcription factor 1 (Pit1, growth hormone factor 1)Pou1Chicken 
POU2F1POU class 2 homeobox 1Pou2Chicken 
Pou2f2-lPou2f2 likePou2Chicken 
POU2F3POU class 2 homeobox 3Pou2Chicken 
POU6F2POU domain, class 6, transcription factor 2Pou6Chicken 
POUVPOU domain class 5 transcription factor 1Pou3Chicken 
Acj6Abnormal chemosensory jumpPou4Beetle 
Acj6-lAcj6 likePou4Beetle 
Pdm3aPou domain 3aPou6Beetle 
Pdm3bPou domain 3bPou6Beetle 
VvlVentral veins lackingPou3Beetle