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POU Class
Families List  Genes List
Proteins encoded by POU class homeobox genes have a ~75 amino acid POU-specific domain (named from the mammalian genes Pit1 (now Pou1f1), OCT1 and OCT2 (now POU2F1 and POU2F2), and nematode unc-86) N-terminal to a 60-amino acid homeodomain. Together the two domains are known as the bipartite POU domain. There are 15 genes with this structure in the human genome, plus a 16th gene (HDX) that possesses a homeodomain related to POU-type homeodomains but lacking a POU-specific domain. Including the divergent HDX gene, this gene class has 16 human genes in seven gene families; there are also eight pseudogenes (Ryan and Rosenfeld 1997, Holland et al. 2007). Amphioxus has seven genes in six families (Takatori et al. 2008).

Reference(s):
Ryan AK, Rosenfeld MG (1997) Genes Dev 1997, 11:1207-1225.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Takatori N et al (2008) Dev Genes Evol 218: 579-590.
 
Families List of Class POU :
Hdx(1)Pou1(1)Pou2(3)Pou3(8)Pou4(4)Pou6(3)    
 
Loci in POU of Frog back to top..
Symbol/LocusNameFamilyOrganismRegulator
hdxhighly divergent homeobox HdxFrog 
oct25POU class V protein oct-25Pou3Frog 
oct60POU class V protein oct-60Pou3Frog 
pou1f1POU class 1 homeobox 1 Pou1Frog 
pou2f1POU class 2 homeobox 1 Pou2Frog 
pou2f3POU class 2 homeobox 3Pou2Frog 
pou3f1POU class 3 homeobox 1 Pou3Frog 
pou3f1bPOU class 3 homeobox 1 Pou3Frog 
pou3f2 Pou3Frog 
pou3f3POU class 3 homeobox 3Pou3Frog 
pou3f4POU class 3 homeobox 4 Pou3Frog 
pou4f1POU class 4 homeobox 1 Pou4Frog 
pou4f1.2POU class 4 homeobox 1Pou4Frog 
pou4f2POU class 4 homeobox 2Pou4Frog 
pou4f3POU class 4 homeobox 3 Pou4Frog 
pou5f1 Pou3Frog 
pou6f1POU class 6 homeobox 1Pou6Frog 
pou6f1b Pou6Frog 
pou6f2POU class 6 homeobox 2 Pou6Frog