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POU Class
Families List  Genes List
Proteins encoded by POU class homeobox genes have a ~75 amino acid POU-specific domain (named from the mammalian genes Pit1 (now Pou1f1), OCT1 and OCT2 (now POU2F1 and POU2F2), and nematode unc-86) N-terminal to a 60-amino acid homeodomain. Together the two domains are known as the bipartite POU domain. There are 15 genes with this structure in the human genome, plus a 16th gene (HDX) that possesses a homeodomain related to POU-type homeodomains but lacking a POU-specific domain. Including the divergent HDX gene, this gene class has 16 human genes in seven gene families; there are also eight pseudogenes (Ryan and Rosenfeld 1997, Holland et al. 2007). Amphioxus has seven genes in six families (Takatori et al. 2008).

Reference(s):
Ryan AK, Rosenfeld MG (1997) Genes Dev 1997, 11:1207-1225.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Takatori N et al (2008) Dev Genes Evol 218: 579-590.
 
Families List of Class POU :
Hdx(1)Pou1(1)Pou2(3)Pou3(4)Pou4(3)Pou5(10)Pou6(2)   
 
Loci in POU of Human back to top..
Symbol/LocusNameFamilyOrganismRegulator
HDXhighly divergent homeoboxHdxHuman 
POU1F1POU class 1 homeobox 1Pou1Human 
POU2F1POU class 2 homeobox 1Pou2Human 
POU2F2POU class 2 homeobox 2Pou2Human 
POU2F3POU class 2 homeobox 3Pou2Human 
POU3F1POU class 3 homeobox 1Pou3Human 
POU3F2POU class 3 homeobox 2Pou3Human 
POU3F3POU class 3 homeobox 3Pou3Human 
POU3F4POU class 3 homeobox 4Pou3Human 
POU4F1POU class 4 homeobox 1Pou4Human 
POU4F2POU class 4 homeobox 2Pou4Human 
POU4F3POU class 4 homeobox 3Pou4Human 
POU5F1POU class 5 homeobox 1Pou5Human 
POU5F1P1POU class 5 homeobox 1 pseudogene 1Pou5Human 
POU5F1P2POU class 5 homeobox 1 pseudogene 2Pou5Human 
POU5F1P3POU class 5 homeobox 1 pseudogene 3Pou5Human 
POU5F1P4POU class 5 homeobox 1 pseudogene 4Pou5Human 
POU5F1P5POU class 5 homeobox 1 pseudogene 5Pou5Human 
POU5F1P6POU class 5 homeobox 1 pseudogene 6Pou5Human 
POU5F1P7POU class 5 homeobox 1 pseudogene 7Pou5Human 
POU5F1P8POU class 5 homeobox 1 pseudogene 8Pou5Human 
POU5F2POU class 5 homeobox 2Pou5Human 
POU6F1POU class 6 homeobox 1Pou6Human 
POU6F2POU class 6 homeobox 2Pou6Human