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POU Class
Families List  Genes List
Proteins encoded by POU class homeobox genes have a ~75 amino acid POU-specific domain (named from the mammalian genes Pit1 (now Pou1f1), OCT1 and OCT2 (now POU2F1 and POU2F2), and nematode unc-86) N-terminal to a 60-amino acid homeodomain. Together the two domains are known as the bipartite POU domain. There are 15 genes with this structure in the human genome, plus a 16th gene (HDX) that possesses a homeodomain related to POU-type homeodomains but lacking a POU-specific domain. Including the divergent HDX gene, this gene class has 16 human genes in seven gene families; there are also eight pseudogenes (Ryan and Rosenfeld 1997, Holland et al. 2007). Amphioxus has seven genes in six families (Takatori et al. 2008).

Reference(s):
Ryan AK, Rosenfeld MG (1997) Genes Dev 1997, 11:1207-1225.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Takatori N et al (2008) Dev Genes Evol 218: 579-590.
 
Families List of Class POU :
Hdx(1)Pou1(1)Pou2(5)Pou3(6)Pou4(4)Pou6(2)    
 
Loci in POU of Zebrafish back to top..
Symbol/LocusNameFamilyOrganismRegulator
brn1.2brain POU domain gene 1.2Pou3Zebrafish 
LOC100001518POU domain, class 6, transcription factor 2-likePou6Zebrafish 
LOC797948highly divergent homeoboxHdxZebrafish 
pou1f1POU domain, class 1, transcription factor 1Pou1Zebrafish 
Pou2-lPou2 likePou2Zebrafish 
pou2f1aPOU class 2 homeobox 1aPou2Zebrafish 
pou2f1bPOU class 2 homeobox 1bPou2Zebrafish 
pou2f2POU domain, class 2, transcription factor 2-likePou2Zebrafish 
pou3f1POU class 3 homeobox 1Pou3Zebrafish 
pou3f2POU class 3 homeobox 2Pou3Zebrafish 
pou3f3aPOU class 3 homeobox 3aPou3Zebrafish 
pou3f3bPOU class 3 homeobox 3bPou3Zebrafish 
pou4f1POU domain, class 4, transcription factor 1Pou4Zebrafish 
pou4f2POU domain, class 4, transcription factor 2Pou4Zebrafish 
pou4f3POU domain, class 4, transcription factor 3Pou4Zebrafish 
pou5f1POU domain, class 5, transcription factor 1Pou3Zebrafish 
pou6f1POU class 6 homeobox 1Pou6Zebrafish 
si:dkey-3j24.1POU domain, class 2, transcription factor 2-likePou2Zebrafish 
zgc:158291zgc:158291Pou4Zebrafish