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PRD Class
Families List  Genes List
The PRD class is the second largest of the homeobox gene classes in animal genomes; like the ANTP class these genes have only been found in animals. The PRD class derives its name from (but is not an abbreviation for) the Paired (Prd) gene of Drosophila. PRD class genes are defined phylogenetically - they form a robust monophyletic group in evolutionary trees of homeodomain sequences. The PRD homeobox class overlaps with the Pax gene class - some but not all Pax genes are in the PRD homeobox gene class, while the vast majority of PRD class homeobox genes are not Pax genes.

There are 9 Pax genes in the human or mouse genomes, defined by presence of a 128 amino acid Paired domain, and of these 7 are members of the PRD homeobox class by virtue of possessing a homeobox: complete homeobox for PAX3, 4, 6 and 7; partial homeobox for PAX2, 5 and 8 (the two human Pax genes lacking a homeobox entirely are PAX1 and PAX9; these are not included in this database). In addition to these 7 homeobox-containing Pax genes, there are a further 43 PRD class genes in the human genome. These 50 genes can be divided into 31 gene families. There are also 24 human pseudogenes generated from these genes, plus an unknown number of DUX repetitive sequences (Holland et al. 2007).

In amphioxus there are 5 Pax genes, and of these 3 are have a partial or complete homeobox (Pax-1/9 and Pon are the two lacking homeobox sequence and therefore excluded; Pon is present in Drosophila and amphioxus, but not human). In addition to these genes, there are a further 27 PRD class genes in amphioxus (Takatori et al. 2008).

Reference(s):
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Takatori N et al (2008) Dev Genes Evol 218: 579-590.
 
Families List of Class PRD :
Arx(2)CG11294(1)Drgx(1)Gsc(1)Hbn(1)Otp(1)Otx(1)Pax2/5/8(1)Pax3/7(3)
Pax4/6(4)Phox(1)Pitx(1)Prop(1)Prrx(1)Rax(1)Repo(1)Shox(1)Uncx(2)
Vsx(3)         
 
Loci in PRD of Fruitfly back to top..
Symbol/LocusNameFamilyOrganismRegulator
alaristalessArxFruitfly 
CG11294CG11294CG11294Fruitfly 
CG32532CG32532PropFruitfly 
CG34340CG34340DrgxFruitfly 
CG34367CG34367ShoxFruitfly 
CG9876CG9876PrrxFruitfly 
eyeyelessPax4/6Fruitfly 
eygeyegonePax4/6Fruitfly 
gsbgooseberryPax3/7Fruitfly 
gsb-ngooseberry-neuroPax3/7Fruitfly 
GscGoosecoidGscFruitfly 
hbnhomeobrainHbnFruitfly 
ococellilessOtxFruitfly 
OdsHOds-site homeoboxUncxFruitfly 
otporthopediaOtpFruitfly 
PHDPPutative homeodomain proteinPhoxFruitfly 
Pph13PvuII-PstI homology 13ArxFruitfly 
prdpairedPax3/7Fruitfly 
Ptx1Ptx1PitxFruitfly 
reporeversed polarityRepoFruitfly 
RxRetinal HomeoboxRaxFruitfly 
svshavenPax2/5/8Fruitfly 
toetwin of eygPax4/6Fruitfly 
toytwin of eyelessPax4/6Fruitfly 
tuptailupVsxFruitfly 
unc-4unc-4UncxFruitfly 
Vsx1 VsxFruitfly 
Vsx2 VsxFruitfly