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PRD Class
Families List  Genes List
The PRD class is the second largest of the homeobox gene classes in animal genomes; like the ANTP class these genes have only been found in animals. The PRD class derives its name from (but is not an abbreviation for) the Paired (Prd) gene of Drosophila. PRD class genes are defined phylogenetically - they form a robust monophyletic group in evolutionary trees of homeodomain sequences. The PRD homeobox class overlaps with the Pax gene class - some but not all Pax genes are in the PRD homeobox gene class, while the vast majority of PRD class homeobox genes are not Pax genes.

There are 9 Pax genes in the human or mouse genomes, defined by presence of a 128 amino acid Paired domain, and of these 7 are members of the PRD homeobox class by virtue of possessing a homeobox: complete homeobox for PAX3, 4, 6 and 7; partial homeobox for PAX2, 5 and 8 (the two human Pax genes lacking a homeobox entirely are PAX1 and PAX9; these are not included in this database). In addition to these 7 homeobox-containing Pax genes, there are a further 43 PRD class genes in the human genome. These 50 genes can be divided into 31 gene families. There are also 24 human pseudogenes generated from these genes, plus an unknown number of DUX repetitive sequences (Holland et al. 2007).

In amphioxus there are 5 Pax genes, and of these 3 are have a partial or complete homeobox (Pax-1/9 and Pon are the two lacking homeobox sequence and therefore excluded; Pon is present in Drosophila and amphioxus, but not human). In addition to these genes, there are a further 27 PRD class genes in amphioxus (Takatori et al. 2008).

Reference(s):
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Takatori N et al (2008) Dev Genes Evol 218: 579-590.
 
Families List of Class PRD :
Arx(2)CG11294(1)Drgx(1)Gsc(1)Hbn(1)Otp(1)Otx(2)Pax2/5/8(1)Pax3/7(3)
Pax4/6(3)Phox(1)Pitx(1)Prop(1)Prrx(1)Rax(1)Repo(1)Shox(1)Uncx(1)
Vsx(1)         
 
Loci in PRD of Honeybee back to top..
Symbol/LocusNameFamilyOrganismRegulator
AlAristalessArxHoneybee 
CG11294CG11294CG11294Honeybee 
DrgxDrgxDrgxHoneybee 
EyEyelessPax4/6Honeybee 
EygEyegonePax4/6Honeybee 
GsbGooseberryPax3/7Honeybee 
GsbnGooseberry neuroPax3/7Honeybee 
GscGoosecoidGscHoneybee 
HbnHomeobrainHbnHoneybee 
Oc1Ocelliless1OtxHoneybee 
Oc2Ocelliless2OtxHoneybee 
OtpOrthopediaOtpHoneybee 
PhoxPhoxPhoxHoneybee 
Pph13Pph13ArxHoneybee 
PrdPairedPax3/7Honeybee 
PropPropPropHoneybee 
PrrxPrrxPrrxHoneybee 
Ptx1Ptx1PitxHoneybee 
RepoReversed polarityRepoHoneybee 
RxRetinal homeoboxRaxHoneybee 
ShoxShoxShoxHoneybee 
SvShavenPax2/5/8Honeybee 
ToyTwin of EyelessPax4/6Honeybee 
Unc4Unc4UncxHoneybee 
VsxVsxVsxHoneybee