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TALE Class
Families List  Genes List
Homeobox genes in the TALE class (TALE = Three Amino Acid Loop Extension) encode proteins with a 63-amino acid homeodomain, with the short extension located between alpha helices 1 and 2. The TALE group is sometimes given the rank of 'superclass' and divided into several classes by the presence of distinct domains outside of the homeodomain - IRX, MKX, MEIS, PBC and TGIF (Bürglin 2005, Bürglin and Mukherjee 2007). We group these genes as one class divided into six gene families. There are 20 human TALE homeobox genes and 10 pseudogenes (Holland et al. 2007); amphioxus has 9 TALE homeobox genes (Takatori et al. 2008).

Reference(s):
Bürglin TR (2005) In: Encyclopedia of Molecular Cell Biology and Molecular
Medicine. Volume 6. 2nd edition. pp. 179-222.
Bürglin TR, Mukherjee K (2007) J Mol Evol 65:137-153.
Holland PWH, Booth HAF, Bruford EA (2007) BMC Biology 5:47.
Takatori N et al (2008) Dev Genes Evol 218: 579-590.
 
Families List of Class TALE :
Irx(11)Meis(5)Mkx(1)Pbx(6)Pknox(4)Tgif(2)    
 
Loci in TALE of Zebrafish back to top..
Symbol/LocusNameFamilyOrganismRegulator
irx1airoquois homeobox protein 1, aIrxZebrafish 
irx1biroquois homeobox protein 1, bIrxZebrafish 
irx2airoquois homeobox protein 2, aIrxZebrafish 
irx3airoquois homeobox protein 3aIrxZebrafish 
irx3biroquois homeobox protein 3bIrxZebrafish 
irx4airoquois homeobox protein 4aIrxZebrafish 
irx4biroquois homeobox protein 4bIrxZebrafish 
irx5airoquois homeobox protein 5aIrxZebrafish 
irx5biroquois homeobox protein 5bIrxZebrafish 
irx6airoquois homeobox protein 6aIrxZebrafish 
irx7iroquois homeobox protein 7IrxZebrafish 
meis1myeloid ecotropic viral integration 1MeisZebrafish 
meis2.1myeloid ecotropic viral integration site 2.1MeisZebrafish 
meis2.2myeloid ecotropic viral integration site 2.2MeisZebrafish 
meis3myeloid ecotropic viral integration site 3MeisZebrafish 
meis4.1amyeloid ecotropic viral integration site 4.1aMeisZebrafish 
mkxamohawk homeobox aMkxZebrafish 
Pbx-lPbx likePbxZebrafish 
pbx1apre-B-cell leukemia transcription factor 1aPbxZebrafish 
pbx2pre-B-cell leukemia transcription factor 2PbxZebrafish 
pbx3apre-B-cell leukemia transcription factor 3aPbxZebrafish 
pbx3bpre-B-cell leukemia transcription factor 3bPbxZebrafish 
pbx4pre-B-cell leukemia transcription factor 4PbxZebrafish 
pknox1.1pbx/knotted 1 homeobox 1.1PknoxZebrafish 
pknox1.2pbx/knotted 1 homeobox 1.2PknoxZebrafish 
pknox1.3homeobox protein PKNOX1-likePknoxZebrafish 
pknox2pbx/knotted 1 homeobox 2PknoxZebrafish 
tgif1TGFB-induced factor homeobox 1TgifZebrafish 
Tgif2homeobox protein TGIF2-likeTgifZebrafish